PAPER Sun L, Zhou XL, Yi HP, Jiang SJ, Yuan H

Lead-induced morphological changes and amyloid precursor protein accumulation in adult rat hippocampus.

Biotech Histochem. 2014 Oct;89(7):513-7. Epub 2014 May 7 PubMed: 24806610

PAPER Gibbs M

Reflections on glycogen and β-amyloid: why does glycogenolytic β2-adrenoceptor stimulation not rescue memory after β-amyloid?

Metab Brain Dis. 2014 May 9; PubMed: 24810634

PAPER Tang Y, Cao J, Li Z, Chen W, Xu A, Mo Y, Yao H, Wang X, Liang C

Effects of Music Electro-Acupuncture and Pulsed Electro-Acupuncture on Behavioral Changes and the Serum β-amyloid Protein in SAMP8 (Senescence Accelerated Mouse Prone 8) Mice.

J Altern Complement Med. 2014 May;20(5):A38. PubMed: 24805589

PAPER

Correction: Screening For Cognitive Impairment In Older Adults.

Ann Intern Med. 2014 Jan 7;160(1) PubMed: 24809304

Gil Rabinovici on 18F-fluorodeoxyglucose positron emission tomography, aging, and apolipoprotein E genotype in cognitively normal persons.

COMMENT This study by Knopman and colleagues from Mayo Clinic demonstrates that decreases in brain glucose metabolism are independently associated with both advancing age and ApoE4 genotype in cognitively normal individuals. The effects of age appeared quite glob

PAPER Haruna Y, Kashihara N, Satoh M, Tomita N, Namikoshi T, Sasaki T, Fujimori T, Xie P, Kanwar YS

Amelioration of progressive renal injury by genetic manipulation of Klotho gene.

Proc Natl Acad Sci U S A. 2007 Feb 13;104(7):2331-6. Epub 2007 Feb 7 PubMed: 17287345

PAPER Kuro-o M

Klotho in chronic kidney disease--what's new?

Nephrol Dial Transplant. 2009 Jun;24(6):1705-8. Epub 2009 Feb 18 PubMed: 19225012

Diego Iacono on Neuropathologic assessment of dementia markers in identical and fraternal twins.

COMMENT What happens in two genetically identical brains after 98 years? What happens in the brains of two not genetically identical, but fraternal and opposite-sex twins after 79 years? What are the similarities and differences between two brains that at the beg

PAPER Park SJ, Shin EJ, Min SS, An J, Li Z, Hee Chung Y, Hoon Jeong J, Bach JH, Nah SY, Kim WK, Jang CG, Kim YS, Nabeshima Y, Nabeshima T, Kim HC

Inactivation of JAK2/STAT3 signaling axis and downregulation of M1 mAChR cause cognitive impairment in klotho mutant mice, a genetic model of aging.

Neuropsychopharmacology. 2013 Jul;38(8):1426-37. Epub 2013 Feb 6 PubMed: 23389690

PAPER Yang H, Fogo AB

Cell senescence in the aging kidney.

J Am Soc Nephrol. 2010 Sep;21(9):1436-9. Epub 2010 Aug 12 PubMed: 20705707

Mark Mattson on Young blood reverses age-related impairments in cognitive function and synaptic plasticity in mice.

COMMENT The new findings of Villeda et al. are remarkable and thought-provoking, as they suggest the possibility that transfusion of blood/plasma from young humans can restore cognitive function in patients with mild cognitive impairment or Alzheimer’s disease. I

Reports Weaken Death Receptor Link to Alzheimer's Disease

RESEARCH NEWS 2014-05-09 Research News [3 January 2024 Editor's note: The paper that prompted the follow-up investigation covered below has been RETRACTED.] Links between death receptor 6, a cell surface protein that triggers pruning of neuronal axons, and Alzheimer's d

PAPER Olsen O, Kallop DY, McLaughlin T, Huntwork-Rodriguez S, Wu Z, Duggan CD, Simon DJ, Lu Y, Easley-Neal C, Takeda K, Hass PE, Jaworski A, O'Leary DD, Weimer RM, Tessier-Lavigne M

Genetic analysis reveals that amyloid precursor protein and death receptor 6 function in the same pathway to control axonal pruning independent of β-secretase.

J Neurosci. 2014 May 7;34(19):6438-47. PubMed: 24806670

PAPER Kallop DY, Meilandt WJ, Gogineni A, Easley-Neal C, Wu T, Jubb AM, Yaylaoglu M, Shamloo M, Tessier-Lavigne M, Scearce-Levie K, Weimer RM

A death receptor 6-amyloid precursor protein pathway regulates synapse density in the mature CNS but does not contribute to Alzheimer's disease-related pathophysiology in murine models.

J Neurosci. 2014 May 7;34(19):6425-37. PubMed: 24806669

Jesus Avila on Activity-dependent tau protein translocation to excitatory synapse is disrupted by exposure to amyloid-beta oligomers.

COMMENT The authors have published a clear and well-performed study on the role of dendritic tau. Several years ago, the dogma was that tau is an intracellular, axonal protein. Now, we know about the multiple faces of tau. Tau could be inside or outside a neuron,