Claire DelBove

Vanderbilt University
Nashville, United States

Travis Rush

UAB
Birmingham

Teresa Leon

International Alzheimer’s Disease Conference 2014

CONFERENCE 2014-06-06 00:00:00-2014-06-07 00:00:00 LKS Faculty of Medicine, The University of Hong Kong, Hong Kong 06 June 2014 to 07 June 2014 View Conference Website 0

Trey Slack

Healthcare
United States

Vinita Vasanth

None

Novel Ubiquitin Modification Ties Two Risk Genes for Parkinsonism

RESEARCH NEWS 2014-04-09 Research News Researchers studying the relationship between the kinase PINK1 and the ubiquitin ligase parkin have discovered that the two interact in a surprising way. Both PINK1 and parkin are risk factors for parkinsonism. According to a report in the M

Eliza Lawrence

PAPER Kondapalli C, Kazlauskaite A, Zhang N, Woodroof HI, Campbell DG, Gourlay R, Burchell L, Walden H, Macartney TJ, Deak M, Knebel A, Alessi DR, Muqit MM

PINK1 is activated by mitochondrial membrane potential depolarization and stimulates Parkin E3 ligase activity by phosphorylating Serine 65.

Open Biol. 2012 May;2(5):120080. PubMed: 22724072

PAPER Ferrer I, Kulisevsky J, Gonzalez G, Escartin A, Chivite A, Casas R

Parvalbumin-immunoreactive neurons in the cerebral cortex and striatum in Huntington’s disease

Neurodegeneration. 1994 Jun;3(2):169–73.

PAPER Hurshman Babbes AR, Powers ET, Kelly JW

Quantification of the thermodynamically linked quaternary and tertiary structural stabilities of transthyretin and its disease-associated variants: the relationship between stability and amyloidosis.

Biochemistry. 2008 Jul 1;47(26):6969-84. Epub 2008 Jun 7 PubMed: 18537267

PAPER Quintas A, Saraiva MJ, Brito RM

The tetrameric protein transthyretin dissociates to a non-native monomer in solution. A novel model for amyloidogenesis.

J Biol Chem. 1999 Nov 12;274(46):32943-9. PubMed: 10551861

Tim Bartels, Dennis Selkoe on Structural mechanism of serum amyloid A-mediated inflammatory amyloidosis.

COMMENT There are some interesting points in the study from the Sun lab that seem to add to general themes found in diseases associated with amyloid aggregation. In all of these diseases, inclusions consisting of an endogenously produced protein mark the progress

PAPER Lu J, Yu Y, Zhu I, Cheng Y, Sun PD

Structural mechanism of serum amyloid A-mediated inflammatory amyloidosis.

Proc Natl Acad Sci U S A. 2014 Apr 8;111(14):5189-94. Epub 2014 Mar 24 PubMed: 24706838

Tao Ma on PPARγ recruitment to active ERK during memory consolidation is required for Alzheimer's disease-related cognitive enhancement.

COMMENT These findings are very interesting and have added to the growing body of evidence linking metabolic disease syndromes to cognitive dysfunction. The authors highlight and propose that the association between a phosphorylated form of ERK kinase and PPARγ p