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APP E599K

MUTATIONS APP 27284167 GRCh37/hg19 rs140304729 G A Exon 14 Point, Missense Coding In cells, reduced Aβ40 secretion, but did not significantly alter Aβ42 secretion nor the Aβ42/Aβ40 ratio. Not applicable. E599K Alzheimer's Disease: Benign, Parkinson's Dise

Therapies Take Aim at Tau

CONFERENCE COVERAGE 2014-08-15 Conference Coverage Researchers continue to target tau in hopes of treating patients with Alzheimer’s or other tauopathies. At the Alzheimer’s Association International Conference 2014 held July 12-17 in Copenhagen, Denmark, scientists presented their lat

Maria Joseph


Max-Planck institute for neurological disease
Bonn, Germany

Blocking Glial Receptor Protects Motor Neurons in Culture and Mice

RESEARCH NEWS 2014-08-14 Research News Neuron-supporting glial cells can rebel in amyotrophic lateral sclerosis, turning against the very motor neurons they are supposed to nurse. Blocking the microglial prostanoid receptor DP1 alleviates this toxicity, according to a paper in th

Michael Sasner on Tau P301S (Line PS19)

COMMENT As of August 2014, we have not seen evidence of the phenotypic drift (later onset of symptoms) in the Jackson Laboratory colony as was reported by Dr. Virginia Lee's lab (Iba et al., 2013). mike.sasner Synthetic tau fibrils mediate transmission of ne

Sue Griffin


University of Arkansas for Medical Sciences
Little Rock, United States

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