PAPER Hegde LG, Yu C, Madhavi C, Araki R, Villarreal J, obedencio G, Kanta A, Sandvick E, Hill C, Dement K, Klein U, McConn D, Martin W, HEGDE S

Comparative efficacy of AHU-377, a potent neprilysin inhibitor, in two rat models of volume-dependent hypertension

BMC Pharmacol. 2011;11(Suppl 1):P33.

PAPER Voors AA, Dorhout B, van der Meer P

The potential role of valsartan + AHU377 (LCZ696) in the treatment of heart failure.

Expert Opin Investig Drugs. 2013 Aug;22(8):1041-7. Epub 2013 May 10 PubMed: 23663006

PAPER Packer M, Califf RM, Konstam MA, Krum H, McMurray JJ, Rouleau JL, Swedberg K

Comparison of omapatrilat and enalapril in patients with chronic heart failure: the Omapatrilat Versus Enalapril Randomized Trial of Utility in Reducing Events (OVERTURE).

Circulation. 2002 Aug 20;106(8):920-6. PubMed: 12186794

Andrew Hua

Manningham Medical Center, Level 5, 200 High Street
Lower Templestowe, (Melbourne), Australia

Awards for Parkinson’s Disease Recognize Pioneering Treatments

COMMUNITY NEWS 2014-09-12 Community News The Albert and Mary Lasker Foundation announced September 8 that Alim Louis Benabid of Joseph Fournier University in Grenoble, France, and Mahlon DeLong of Emory University School of Medicine in Atlanta will receive the 2014 Lasker-DeBakey

PAPER DeLong MR, Benabid AL

Discovery of High-Frequency Deep Brain Stimulation for Treatment of Parkinson Disease: 2014 Lasker Award.

JAMA. 2014 Sep 8; PubMed: 25198255

PAPER Rajput AH

An open letter to the Committee on The Nobel Prize in Medicine.

Parkinsonism Relat Disord. 2001 Apr;7(2):149-55. PubMed: 18591152

PAPER Limousin P, Pollak P, Benazzouz A, Hoffmann D, Le Bas JF, Broussolle E, Perret JE, Benabid AL

Effect of parkinsonian signs and symptoms of bilateral subthalamic nucleus stimulation.

Lancet. 1995 Jan 14;345(8942):91-5. PubMed: 7815888

PAPER Langston JW, Langston EB, Irwin I

MPTP-induced parkinsonism in human and non-human primates--clinical and experimental aspects.

Acta Neurol Scand Suppl. 1984;100:49-54. PubMed: 6333134

CRISPR: A New Tool For Gene Editors

SERIES CRISPR Gene Editing—Poised to Revolutionize Neuroscience? Neuroscientists Probe CRISPR Transgenics and Treatment Paradigms

Neuroscientists Probe CRISPR Transgenics and Treatment Paradigms

RESEARCH NEWS 2014-09-12 Research News CRISPR, a gene-editing technology borrowed from humble bacteria, has taken the biomedical research world by storm. Researchers can use the technique to inactivate genes, add point mutations, or insert entire genes into virtually any spot in

Nikolaos K. Robakis on Evidence for lymphatic Aβ clearance in Alzheimer's transgenic mice.

COMMENT This is a very important paper from Dr. Pappolla and associates. It demonstrates for the first time that the lymphatic system may play a substantive role in the clearance of Aβ peptides from the brain. Impaired clearance of amyloid may play a major role i

Thomas Wisniewski on Evidence for lymphatic Aβ clearance in Alzheimer's transgenic mice.

COMMENT This is a most interesting paper. Inadequate clearance of Aβ from the brain is considered to play a critical role in amyloid accumulation of late-onset Alzheimer's disease (LOAD). Despite the research efforts of the last three decades, the role of th

PAPER Tsai SQ, Wyvekens N, Khayter C, Foden JA, Thapar V, Reyon D, Goodwin MJ, Aryee MJ, Joung JK

Dimeric CRISPR RNA-guided FokI nucleases for highly specific genome editing.

Nat Biotechnol. 2014 Jun;32(6):569-76. Epub 2014 Apr 25 PubMed: 24770325

PAPER Veres A, Gosis BS, Ding Q, Collins R, Ragavendran A, Brand H, Erdin S, Talkowski ME, Musunuru K

Low incidence of off-target mutations in individual CRISPR-Cas9 and TALEN targeted human stem cell clones detected by whole-genome sequencing.

Cell Stem Cell. 2014 Jul 3;15(1):27-30. PubMed: 24996167