PAPER Olazarán J, González B, Osa-Ruiz E, Felipe-Ruiz S, Boyano I, Fontani V, Castagna A, Mendoza C, Zea MA, Frades B, Rinaldi S, Martínez-Martín P

Motor effects of radio electric asymmetric conveyer in Alzheimer's disease: results from a cross-over trial.

J Alzheimers Dis. 2014;42(1):325-32. PubMed: 24898637

PAPER Moon M, Choi JG, Kim SY, Oh MS

Bombycis excrementum reduces amyloid-β oligomer-induced memory impairments, neurodegeneration, and neuroinflammation in mice.

J Alzheimers Dis. 2014;41(2):599-613. PubMed: 24898636

PAPER Roy K, Pepin LC, Philiossaint M, Lorius N, Becker JA, Locascio JJ, Rentz DM, Sperling RA, Johnson KA, Marshall GA

Regional fluorodeoxyglucose metabolism and instrumental activities of daily living across the Alzheimer's disease spectrum.

J Alzheimers Dis. 2014;42(1):291-300. PubMed: 24898635

PAPER Barbisin M, Vanni S, Schmädicke AC, Montag J, Motzkus D, Opitz L, Salinas-Riester G, Legname G

Gene expression profiling of brains from bovine spongiform encephalopathy (BSE)-infected cynomolgus macaques.

BMC Genomics. 2014 Jun 5;15:434. PubMed: 24898206

PAPER Zwan MD, Ossenkoppele R, Tolboom N, Beunders AJ, Kloet RW, Adriaanse SM, Boellaard R, Windhorst AD, Raijmakers P, Adams H, Lammertsma AA, Scheltens P, van der Flier WM, van Berckel BN

Comparison of Simplified Parametric Methods for Visual Interpretation of 11C-Pittsburgh Compound-B PET Images.

J Nucl Med. 2014 Jun 4;55(8):1305-1307. PubMed: 24898026

PAPER Rosse G

Dihydrooxazines As Inhibitors of BACE-1 or BACE-2.

ACS Med Chem Lett. 2013 May 9;4(5):433-4. Epub 2013 Mar 19 PubMed: 24900690

PAPER Cukierman-Yaffe T, Bosch J, Diaz R, Dyal L, Hancu N, Hildebrandt P, Lanas F, Lewis BS, Marre M, Yale JF, Yusuf S, Gerstein HC, ORIGIN Investigators

Effects of basal insulin glargine and omega-3 fatty acid on cognitive decline and probable cognitive impairment in people with dysglycaemia: a substudy of the ORIGIN trial.

Lancet Diabetes Endocrinol. 2014 Jul;2(7):562-72. Epub 2014 Jun 2 PubMed: 24898834

PAPER Whitmer RA

Cognitive impairment in ORIGIN: timing is everything.

Lancet Diabetes Endocrinol. 2014 Jul;2(7):531-2. Epub 2014 Jun 2 PubMed: 24898832

PAPER András IE, Toborek M

HIV-1 stimulates nuclear entry of amyloid beta via dynamin dependent EEA1 and TGF-β/Smad signaling.

Exp Cell Res. 2014 Apr 15;323(1):66-76. Epub 2014 Jan 31 PubMed: 24491918

PAPER Fowler SW, Chiang AC, Savjani RR, Larson ME, Sherman MA, Schuler DR, Cirrito JR, Lesné SE, Jankowsky JL

Genetic modulation of soluble Aβ rescues cognitive and synaptic impairment in a mouse model of Alzheimer's disease.

J Neurosci. 2014 Jun 4;34(23):7871-85. PubMed: 24899710

Terrence Town on TREM2 Mystery: Altered Microglia, No Effect on Plaques

COMMENT In this interesting report, David Holtzman’s group has provided the first test of TREM2 heterozygous loss in a mouse model of cerebral amyloidosis (APPPS1-21). Their report is both timely and provocative, given recent GWAS results implicating a single all

Michael Heneka on TREM2 Mystery: Altered Microglia, No Effect on Plaques

COMMENT Genetic variants in TREM2 have been found to increase the risk of developing Alzheimer´s disease. This paper by Ullrich and colleagues aims to identify molecular mechanisms underlying this risk. Previously, TREM2 expression has been reported in microglia,

TREM2 Mystery: Altered Microglia, No Effect on Plaques

RESEARCH NEWS 2014-06-06 Research News Since the 2012 discovery that mutations in the microglial gene TREM2 increase Alzheimer’s risk by about as much the ApoE4 allele does, researchers have tried to figure out why (see Nov 2012 news story). TREM2 being a microglial receptor, one

David Holtzman on Effect of 1 night of total sleep deprivation on cerebrospinal fluid β-amyloid 42 in healthy middle-aged men: a randomized clinical trial.

COMMENT This paper by Ooms and colleagues studies the effect of sleep deprivation in humans on cerebrospinal fluid (CSF) Aβ40, Aβ42, tau, p-tau, and total protein in middle-aged individuals with lumbar catheters. It is found that CSF Aβ42 decreased in those who h

While You Were Sleeping—Synapses Forged, Amyloid Purged

RESEARCH NEWS 2014-06-06 Research News As you lay yourself down to sleep, pray your neurons pick good memories to keep. A paper in the June 6 Science posits that during sleep, neurons reinforce freshly learned skills by sprouting new dendritic spines, and hence the number of syna