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International Alzheimer’s Disease Conference 2014
CONFERENCE 2014-06-06 00:00:00-2014-06-07 00:00:00 LKS Faculty of Medicine, The University of Hong Kong, Hong Kong 06 June 2014 to 07 June 2014 View Conference Website 0
Trey Slack
HealthcareUnited States
Vinita Vasanth
None
Novel Ubiquitin Modification Ties Two Risk Genes for Parkinsonism
RESEARCH NEWS 2014-04-09 Research News Researchers studying the relationship between the kinase PINK1 and the ubiquitin ligase parkin have discovered that the two interact in a surprising way. Both PINK1 and parkin are risk factors for parkinsonism. According to a report in the M
Eliza Lawrence
PAPER Kondapalli C, Kazlauskaite A, Zhang N, Woodroof HI, Campbell DG, Gourlay R, Burchell L, Walden H, Macartney TJ, Deak M, Knebel A, Alessi DR, Muqit MM
PINK1 is activated by mitochondrial membrane potential depolarization and stimulates Parkin E3 ligase activity by phosphorylating Serine 65.
Open Biol. 2012 May;2(5):120080. PubMed: 22724072PAPER Ferrer I, Kulisevsky J, Gonzalez G, Escartin A, Chivite A, Casas R
Parvalbumin-immunoreactive neurons in the cerebral cortex and striatum in Huntington’s disease
Neurodegeneration. 1994 Jun;3(2):169–73.PAPER Hurshman Babbes AR, Powers ET, Kelly JW
Quantification of the thermodynamically linked quaternary and tertiary structural stabilities of transthyretin and its disease-associated variants: the relationship between stability and amyloidosis.
Biochemistry. 2008 Jul 1;47(26):6969-84. Epub 2008 Jun 7 PubMed: 18537267PAPER Quintas A, Saraiva MJ, Brito RM
The tetrameric protein transthyretin dissociates to a non-native monomer in solution. A novel model for amyloidogenesis.
J Biol Chem. 1999 Nov 12;274(46):32943-9. PubMed: 10551861Tim Bartels, Dennis Selkoe on Structural mechanism of serum amyloid A-mediated inflammatory amyloidosis.
COMMENT There are some interesting points in the study from the Sun lab that seem to add to general themes found in diseases associated with amyloid aggregation. In all of these diseases, inclusions consisting of an endogenously produced protein mark the progress
PAPER Lu J, Yu Y, Zhu I, Cheng Y, Sun PD
Structural mechanism of serum amyloid A-mediated inflammatory amyloidosis.
Proc Natl Acad Sci U S A. 2014 Apr 8;111(14):5189-94. Epub 2014 Mar 24 PubMed: 24706838Tao Ma on PPARγ recruitment to active ERK during memory consolidation is required for Alzheimer's disease-related cognitive enhancement.
COMMENT These findings are very interesting and have added to the growing body of evidence linking metabolic disease syndromes to cognitive dysfunction. The authors highlight and propose that the association between a phosphorylated form of ERK kinase and PPARγ p
Katie Evans
Katiebrisbane, Australia
Claire Lucas
Alzheimer's Research UKUnited Kingdom
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