Cécile Martin

PAPER Walsh DT, Perry VH, Minghetti L

Cyclooxygenase-2 is highly expressed in microglial-like cells in a murine model of prion disease.

Glia. 2000 Feb 15;29(4):392-6. PubMed: 10652449

PAPER Minghetti L, Walsh DT, Levi G, Perry VH

In vivo expression of cyclooxygenase-2 in rat brain following intraparenchymal injection of bacterial endotoxin and inflammatory cytokines.

J Neuropathol Exp Neurol. 1999 Nov;58(11):1184-91. PubMed: 10560661

Mathias Jucker on Like Prions, Tau Strains Are True to Form

COMMENT This is a very carefully done and exciting study that convincingly demonstrates the existence of tau conformers ("strains") in living systems. In vivo strains have been suggested previously for tau (e.g., Clavaguera et al., 2013), synuclein (e.g

Like Prions, Tau Strains Are True to Form

RESEARCH NEWS 2014-05-22 Research News Misfolded proteins that cause neurodegenerative diseases act an awful lot like prions, even if they do not fit the exact definition. For example, Aβ and tau are not considered infectious from person to person, and no one has shown that disti

hTau.P301S

RESEARCH MODELS Summary This transgenic model of tauopathy expresses MAPT with the P301S mutation, which is associated with autosomal-dominant disease in humans. The hTau.P301S model recapitulates several molecular, cellular, and behavioral features of human tauopathy, i

Alice Lepelley

Jucker, Walker, Yan, and Shen Win 2014 MetLife Awards

COMMUNITY NEWS 2014-05-22 Community News Mathias Jucker, Lary Walker, and Riqiang Yan share this year's MetLife Foundation Award in Medical Research. Jucker, from the University of Tubingen, Germany, and Walker, from Emory University, Atlanta, were recognized for their studie

PAPER Groot AJ, Habets R, Yahyanejad S, Hodin CM, Reiss K, Saftig P, Theys J, Vooijs M

Regulated proteolysis of NOTCH2 and NOTCH3 receptors by ADAM10 and presenilins.

Mol Cell Biol. 2014 Aug;34(15):2822-32. Epub 2014 May 19 PubMed: 24842903

PAPER Welzel AT, Maggio JE, Shankar GM, Walker DE, Ostaszewski BL, Li S, Klyubin I, Rowan MJ, Seubert P, Walsh DM, Selkoe DJ

Secreted amyloid β-proteins in a cell culture model include N-terminally extended peptides that impair synaptic plasticity.

Biochemistry. 2014 Jun 24;53(24):3908-21. PubMed: 24840308

PAPER Meininger V, Pradat PF, Corse A, Al-Sarraj S, Rix Brooks B, Caress JB, Cudkowicz M, Kolb SJ, Lange D, Leigh PN, Meyer T, Milleri S, Morrison KE, Orrell RW, Peters G, Rothstein JD, Shefner J, Lavrov A, Williams N, Overend P, Price J, Bates S, Bullman J, Krull D, Berges A, Abila B, Meno-Tetang G, Wurthner J

Safety, pharmacokinetic, and functional effects of the nogo-a monoclonal antibody in amyotrophic lateral sclerosis: a randomized, first-in-human clinical trial.

PLoS One. 2014;9(5):e97803. Epub 2014 May 19 PubMed: 24841795

PAPER Mochizuki Y, Kawata A, Maruyama H, Homma T, Watabe K, Kawakami H, Komori T, Mizutani T, Matsubara S

A Japanese patient with familial ALS and a p.K510M mutation in the gene for FUS (FUS) resulting in the totally locked-in state.

Neuropathology. 2014 Oct;34(5):504-9. Epub 2014 May 19 PubMed: 24841222

PAPER Deng H, Gao K, Jankovic J

The role of FUS gene variants in neurodegenerative diseases.

Nat Rev Neurol. 2014 Jun;10(6):337-48. Epub 2014 May 20 PubMed: 24840975

PAPER

Retraction notice to: Directed conversion of Alzheimer’s disease patient skin fibroblasts into functional neurons.

Cell. 2014 Apr 10;157(2):514. PubMed: 24843893

PAPER Gudala K, Bansal D, Schifano F, Bhansali A

Diabetes mellitus and risk of dementia: A meta-analysis of prospective observational studies.

J Diabetes Investig. 2013 Nov 27;4(6):640-50. Epub 2013 Apr 26 PubMed: 24843720