Translational Neuroscience in Psychiatry: Light at the End of the Tunnel

CONFERENCE 2014-04-08 00:00:00-2014-04-08 00:00:00 The New York Academy of Sciences, New York, NY, U.S.A. 08 April 2014 Progress developing new and more effective treatments for psychiatric disorders, particularly depression and schizophrenia, has been stymied in part because of a lack of quantitative end

Diego Iacono

Biomedical Research Institute of New Jersey (BRInj) - MidAtlantic Neonatology Associates (MANA) & Atlantic Neuroscience Institute, Atlantic Health System (AHS), NJ
Cedar Knolls, NJ, United States

Meike Vernooij on Prevalence of cortical superficial siderosis in a memory clinic population.

COMMENT This present report by Zonneveld et al. is interesting as it shows that in a large memory clinic population, there is 1) a link between AD and superficial siderosis (SS), 2) a link between microbleeds and SS in AD patients, and 3) a higher prevalence of S

Kejal Kantarci on Prevalence of cortical superficial siderosis in a memory clinic population.

COMMENT The study by Kantarci et al. investigating the focal hemosiderin deposits in the form of microhemorrhages and superficial siderosis in the ADNI cohort (Kantarci et al., 2013), reported that a majority of individuals with superficial siderosis also have mi

Alzheimer’s Disease Linked to Superficial Siderosis. What Does it Mean?

RESEARCH NEWS 2014-02-28 Research News People with Alzheimer’s disease are nearly seven times more likely than other people to harbor superficial siderosis (SS)—a serpentine pattern of blood deposits that snake the brain’s surface, researchers reported in the February 25 Neurolog

PAPER Charidimou A, Jäger RH, Fox Z, Peeters A, Vandermeeren Y, Laloux P, Baron JC, Werring DJ

Prevalence and mechanisms of cortical superficial siderosis in cerebral amyloid angiopathy.

Neurology. 2013 Aug 13;81(7):626-32. Epub 2013 Jul 17 PubMed: 23864315

PAPER Linn J, Halpin A, Demaerel P, Ruhland J, Giese AD, Dichgans M, van Buchem MA, Bruckmann H, Greenberg SM

Prevalence of superficial siderosis in patients with cerebral amyloid angiopathy.

Neurology. 2010 Apr 27;74(17):1346-50. PubMed: 20421578

PAPER Linn J, Herms J, Dichgans M, Brückmann H, Fesl G, Freilinger T, Wiesmann M

Subarachnoid hemosiderosis and superficial cortical hemosiderosis in cerebral amyloid angiopathy.

AJNR Am J Neuroradiol. 2008 Jan;29(1):184-6. Epub 2007 Oct 18 PubMed: 17947366

Gene Silencing in Fragile X Syndrome Explained?

RESEARCH NEWS 2014-02-28 Research News It is a decades-old mystery: How does a small DNA repeat cause Fragile X syndrome, the most common form of inherited mental retardation? Researchers led by Samie Jaffrey, Cornell University, New York, report in the February 28 Science that a

PAPER Hagerman RJ

Lessons from fragile X regarding neurobiology, autism, and neurodegeneration.

J Dev Behav Pediatr. 2006 Feb;27(1):63-74. PubMed: 16511373

PAPER Wu JQ, Habegger L, Noisa P, Szekely A, Qiu C, Hutchison S, Raha D, Egholm M, Lin H, Weissman S, Cui W, Gerstein M, Snyder M

Dynamic transcriptomes during neural differentiation of human embryonic stem cells revealed by short, long, and paired-end sequencing.

Proc Natl Acad Sci U S A. 2010 Mar 16;107(11):5254-9. Epub 2010 Mar 1 PubMed: 20194744

PAPER Sun Q, Csorba T, Skourti-Stathaki K, Proudfoot NJ, Dean C

R-loop stabilization represses antisense transcription at the Arabidopsis FLC locus.

Science. 2013 May 3;340(6132):619-21. PubMed: 23641115

PAPER Eiges R, Urbach A, Malcov M, Frumkin T, Schwartz T, Amit A, Yaron Y, Eden A, Yanuka O, Benvenisty N, Ben-Yosef D

Developmental study of fragile X syndrome using human embryonic stem cells derived from preimplantation genetically diagnosed embryos.

Cell Stem Cell. 2007 Nov;1(5):568-77. PubMed: 18371394

PAPER Verkerk AJ, Pieretti M, Sutcliffe JS, Fu YH, Kuhl DP, Pizzuti A, Reiner O, Richards S, Victoria MF, Zhang FP

Identification of a gene (FMR-1) containing a CGG repeat coincident with a breakpoint cluster region exhibiting length variation in fragile X syndrome.

Cell. 1991 May 31;65(5):905-14. PubMed: 1710175

Kejal Kantarci

Mayo Clinic
Rochester, United States