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Searching for Evidence of Neurodegeneration in the Blood

RESEARCH NEWS 2014-08-08 Research News Given the invasiveness and expense of measuring brain biomarkers for neurodegenerative diseases, researchers are searching for alternatives. Despite little success thus far, they continue to comb the complex jumble of proteins and molecules

PAPER Stefansson H, Helgason A, Thorleifsson G, Steinthorsdottir V, Masson G, Barnard J, Baker A, Jonasdottir A, Ingason A, Gudnadottir VG, Desnica N, Hicks A, Gylfason A, Gudbjartsson DF, Jonsdottir GM, Sainz J, Agnarsson K, Birgisdottir B, Ghosh S, Olafsdottir A, Cazier JB, Kristjansson K, Frigge ML, Thorgeirsson TE, Gulcher JR, Kong A, Stefansson K

A common inversion under selection in Europeans.

Nat Genet. 2005 Feb;37(2):129-37. Epub 2005 Jan 16 PubMed: 15654335

Treating Midlife Hypertension Helps Preserve Cognition in Old Age

RESEARCH NEWS 2014-08-08 Research News High blood pressure in middle age takes a toll on brain function in late life, confirms a new longitudinal study. Published in the August 4 JAMA Neurology, the data come from the Atherosclerosis Risk in Communities (ARIC) Neurocognitive Stud

PAPER Toyn JH Jr, Thompson LA, Lentz KA, Meredith JE, Burton CR, Sankaranararyanan S, Guss V, Hall T, Iben LG, Krause CM, Krause R, Lin XA, Pierdomenico M, Polson C, Robertson AS, Denton RR, Grace JE, Morrison J, Raybon J, Zhuo X, Snow K, Padmanabha R, Agler M, Esposito K, Harden D, Prack M, Varma S, Wong V, Zhu Y, Zvyaga T, Gerritz S, Marcin LR, Higgins MA, Shi J, Wei C, Cantone JL, Drexler DM, Macor JE, Olson RE, Ahlijanian MK, Albright CF

Identification and Preclinical Pharmacology of the γ-Secretase Modulator BMS-869780.

Int J Alzheimers Dis. 2014;2014:431858. Epub 2014 Jul 8 PubMed: 25097793

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