Research Models

TMHT (Thy-1 mutated human tau)

Synonyms: TAU 441, hTAU441, TAU441 V337M R406W

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Species: Mouse
Genes: MAPT
Mutations: MAPT V337M (Seattle Family A), MAPT R406W
Modification: MAPT: Transgenic
Disease Relevance: Alzheimer's Disease
Strain Name: N/A
Genetic Background: C57Bl/6xDBA
Availability: QPS-Austria

Neuropathology

Increased total tau and phosphorylated tau species (Thr181, Ser199, Thr231) in the amygdala and hippocampus starting at three months.

Cognition/Behavior

Spatial memory deficits starting at five months by the Morris water maze. Olfactory deficits at five months indicated by the buried food test. No motor deficits (by rotarod, beam walk) or depressive behavior as indicated by the forced swim test.

Modification Details

Transgene consists of human MAPT Tau441 (2N/4R) with mutations V337M and R406W under control of the Thy1 promoter.

Availability

Available through QPS-Austria (office-austria@qps.com). Available as a live stock.

Phenotype Timeline

When visualized, these models will distributed over a 18 month timeline demarcated at the following intervals: 1mo, 3mo, 6mo, 9mo, 12mo, 15mo, 18mo+.

Observed

Absent

  • Plaques

Unknown

Plaques

Absent.

Tangles

Tangles at 4 months and progress with age.

Cognitive Impairment

Cognitive impairment by 5 months as measured by the Morris Water Maze.

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Comments

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References

External Citations

  1. QPS-Austria

Further Reading

No Available Further Reading