Research Models

TgAPParc

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Species: Mouse
Genes: APP
Mutations: APP E693G (Arctic)
Modification: APP: Transgenic
Disease Relevance: Alzheimer's Disease
Strain Name: B6CBA-Tg(Thy1.2-hAPParc)
Genetic Background: C57BL/6-CBA
Availability: Available through Annica Rönnbäck.

Summary

This transgenic mouse line expresses human APP with the Arctic mutation. Mutant human APP is expressed at about three-fold higher levels than endogenous murine APP. The mice develop an age-dependent progression of amyloid pathology that starts with intracellular Aβ accumulation. Around 7-9 months diffuse extracellular Aβ deposits develop in the subiculum and then spread to interconnected brain regions, such as the retrosplenial granular cortex, thalamus, and mammillary bodies by 12-15 months. Neuropathology is more severe in female mice than males, but males exhibit a similar spatiotemporal pattern of amyloid development (Rönnbäck et al., 2011).

Modification Details

Transgenic mice with human APP (isoform 695) bearing the Arctic APP mutation (E693G).

Availability

Available through Annica Rönnbäck.

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References

Paper Citations

  1. . Amyloid neuropathology in the single Arctic APP transgenic model affects interconnected brain regions. Neurobiol Aging. 2011 Aug 29; PubMed.

Other Citations

  1. Annica Rönnbäck

Further Reading

Papers

  1. . Modulation of the endoplasmic reticulum-mitochondria interface in Alzheimer's disease and related models. Proc Natl Acad Sci U S A. 2013 May 7;110(19):7916-21. PubMed.
  2. . Amyloid precursor protein accumulates in aggresomes in response to proteasome inhibitor. Neurochem Int. 2012 Apr;60(5):533-42. PubMed.