Genes: APP, RAGE
Mutations: APP KM670/671NL (Swedish), APP V717F (Indiana)
Modification: APP: Transgenic; RAGE: Transgenic
Disease Relevance: Alzheimer's Disease
Strain Name: N/A
Genetic Background: C57BL/6
Availability: Available through Shirley ShiDu Yan.
Significantly increased activation of microglia and astrocytes compared to mice expressing mutant APP alone.
Tg-mAPP/RAGE mice display abnormalities in spatial learning and memory at age three to four months of age, whereas deficits occur later in mice expressing mutant APP alone and are less severe.
Mice overexpressing wild-type RAGE driven by the PDGF-β promoter were crossed with mice expressing human APP carrying the Swedish and Indiana mutations driven by PDGF-β promoter (The Jackson Lab: Stock# 004661-now extinct).
Mice expressing a dominant-negative form of RAGE (Tg-mAPP/DN-RAGE) were generated in parallel.