Research Models

Tg-mAPP/RAGE

Synonyms: APP/RAGE

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Species: Mouse
Genes: APP, RAGE
Mutations: APP KM670/671NL (Swedish), APP V717F (Indiana)
Modification: APP: Transgenic; RAGE: Transgenic
Disease Relevance: Alzheimer's Disease
Strain Name: N/A
Genetic Background: C57BL/6
Availability: Available through Shirley ShiDu Yan.

Neuropathology

Significantly increased activation of microglia and astrocytes compared to mice expressing mutant APP alone.

Cognition/Behavior

Tg-mAPP/RAGE mice display abnormalities in spatial learning and memory at age three to four months of age, whereas deficits occur later in mice expressing mutant APP alone and are less severe.

Modification Details

Mice overexpressing wild-type RAGE driven by the PDGF-β promoter were crossed with mice expressing human APP carrying the Swedish and Indiana mutations driven by PDGF-β promoter (The Jackson Lab: Stock# 004661-now extinct).

Related Strains

Mice expressing a dominant-negative form of RAGE (Tg-mAPP/DN-RAGE) were generated in parallel.

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References

Research Models Citations

  1. Tg-mAPP/DN-RAGE

Other Citations

  1. Shirley ShiDu Yan

External Citations

  1. The Jackson Lab: Stock# 004661

Further Reading