Research Models

Commonly Used Mouse Models

Name Genes Mutations Modification Disease Neuropathology Behavior/Cognition Visualization Promoter/Regulatory Elements Genetic Background Strain Name Other Phenotypes Availability Primary Paper
APP, PSEN1 APP K670_M671delinsNL (Swedish), APP I716V (Florida), APP V717I (London), PSEN1 M146L (A>C), PSEN1 L286V APP: Transgenic; PSEN1: Transgenic Alzheimer's Disease Amyloid pathology starting at 2 months, including amyloid plaques. Accumulation of intraneuronal Aβ before amyloid deposition. Gliosis and synapse degeneration. Neuron loss in cortical layer 5 and subiculum. No neurofibrillary tangles. Age-dependent memory deficits including spatial memory, stress-related memory, and memory stablization. Motor phenotype. Yes C57BL/6 x SJL B6SJL-Tg(APPSwFlLon,PSEN1*M146L*L286V)6799Vas/Mmjax The Jackson Lab; available through the JAX MMRRC Stock# 034840; Live. Oakley et al., 2006
MAPT MAPT P301S MAPT: Transgenic Alzheimer's Disease, Frontotemporal Dementia Neuron loss and brain atrophy by eight to 12 months, especially in the hippocampus and spreading to the neocortex and entorhinal cortex. Neurofibrillary tangles in the neocortex, amygdala, hippocampus, brain stem, and spinal cord. Neuroinflammation with microgliosis and astrocytosis. Impairments in spatial memory and learning ability in Morris water maze. Paralysis at seven to 10 months associated with a hunched-back posture followed by feeding difficulties. About 80 percent mortality by 12 months with median survival of about nine months. Yes (C57BL/6 x C3H)F1 B6;C3-Tg(Prnp-MAPT*P301S)PS19Vle/J Clasping and limb retraction when lifted by the tail at three months, followed by limb weakness and brain atrophy. Homozygous females do not mate. The Jackson Lab: Stock# 008169; Live. Research with this model is available from QPS Austria. Yoshiyama et al., 2007