Research Models
Selected Results
1 Models
| Name | Other Names | Strain Name | Genetic Background | Gene | Mutation | Modification Info | Modification | Disease | Neuropathology | Behavior/Cognition | Other Phenotype | Availability | Primary Paper | Visualization | |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Mouse Models (1) |
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| PS-1 P264L knock-in | R1 line of the ES cells (129 mouse strain) | PSEN1 | PSEN1 P264L | An exon replacement strategy was used to generate mouse lines carrying a targeted mutation in their endogenous presenilin-1 gene. A proline-to-leucine substitution was targeted to codon 264 in exon 8 by homologous recombination in embryonic stem (ES) cells. Cre-lox system to remove the neomycin selection cassette from the targeted gene. | PSEN1: Knock-In | Alzheimer's Disease | Not observed. | Unknown. | Unknown | Siman et al., 2000 | No | ||||