Research Models

NSE-hPS2(N141I)

Tools

Back to the Top

Species: Mouse
Genes: PSEN2
Mutations: PSEN2 N141I
Modification: PSEN2: Transgenic
Disease Relevance: Alzheimer's Disease
Strain Name: N/A
Genetic Background: C57BL/6× DBA/2
Availability: Unknown

Modification Details

Transgene containing human PSEN2 carrying the N141I mutation driven by the neuron-specific enolase (NSE) promoter.

Neuropathology

Not observed.

Cognition/Behavior

Behavioral deficits in the water maze at 12 months in mice expressing mutant as well as wild-type PSEN2, including longer escape latencies than wild-type mice, but no difference in swimming speed.

Other Phenotype

Expression of PSEN2 was higher in mice expressing mutant as well as wild-type PSEN2 compared to age-matched, non-transgenic mice. Alterations in levels of Aβ42, caspase-3 and Cox-2 proteins.

Last Updated: 06 Apr 2022

COMMENTS / QUESTIONS

No Available Comments

Make a comment or submit a question

To make a comment you must login or register.

References

No Available References

Further Reading

No Available Further Reading