Research Models

ArcAβ

Synonyms: arcAbeta

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Species: Mouse
Genes: APP
Mutations: APP KM670/671NL (Swedish), APP E693G (Arctic)
Modification: APP: Transgenic
Disease Relevance: Alzheimer's Disease
Strain Name: N/A
Genetic Background: Origin: B6D2 F1
Availability: Unknown.

Modification Details

These mice express a human APP695 transgene containing the Swedish (K670N/M671L) and Arctic (E693G) mutations, which were introduced by site-directed mutagenesis.

Neuropathology

At six months, intracellular punctate deposits of Aβ are abundant in the cortex and hippocampus, but overt β-amyloid plaques are not apparent until 9 to 15 months. Severe cerebral amyloid angiopathy is also present at this age with dense Aβ aggregates in the walls of blood vessels and spreading into the parenchyma (Knobloch et al., 2007).

Cognition/Behavior

Cognitive impairment is seen at the age of six months as measured in the Morris water maze and Y-maze (Knobloch et al., 2007).

Phenotype Timeline

When visualized, these models will distributed over a 18 month timeline demarcated at the following intervals: 1mo, 3mo, 6mo, 9mo, 12mo, 15mo, 18mo+.

Observed

Absent

  • Tangles

Unknown

  • Synaptic Loss

Plaques

Between 9 and 15 months of age β-amyloid plaques became prominent. Plaques had a characteristic dense core morphology which differed from the cotton wool-like structure of plaques seen with the Swedish mutation alone.

Tangles

Absent.

Synaptic Loss

Unknown.

Cognitive Impairment

Cognitive impairment measured from the age of 6 months in the Morris water maze and Y-maze as well as in active avoidance behavior.

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References

Paper Citations

  1. . Intracellular Abeta and cognitive deficits precede beta-amyloid deposition in transgenic arcAbeta mice. Neurobiol Aging. 2007 Sep;28(9):1297-306. PubMed.

Further Reading

Papers

  1. . RAGE does not affect amyloid pathology in transgenic ArcAbeta mice. Neurodegener Dis. 2009;6(5-6):270-80. PubMed.