Mutations: APP KM670/671NL (Swedish)
Modification: APP: Transgenic
Disease Relevance: Alzheimer's Disease
Strain Name: B6.Cg-Tg(Prnp-App/APPswe)E1-2Dbo/Mmjax
Genetic Background: C3H/HeJ x C57BL/6J; backcrossed to C57BL/6J
Availability: The Jackson Lab; available through the JAX MMRRC Stock# 034835; Cryopreserved
These transgenic mice express a chimeric mouse/human APP carrying the Swedish mutation under the control of the mouse prion protein promoter. This line, E1-2, was generated in parallel with line C3-3 which also expresses APP with the Swedish mutation. Mice that are hemizygous for the transgene are viable and fertile and express mutant human APP at levels about three-fold higher than endogenous murine APP. They develop elevated Aβ at advanced age, with low levels at 6-14 months and higher levels at 24-26 months. On a noncongenic background some deficits in cognitive performance were observed in aging animals, but these deficits largely disappeared after the mice were back-crossed and became congenic (Savonenko et al., 2003).
This model was previously available through The Jackson Lab as Stock# 006005.
Transgene is a chimeric mouse/human APP (isoform 695) with a "humanized" Aβ domain carrying the Swedish mutation under the control of the mouse prion protein promoter.
Research Models Citations
- Savonenko AV, Xu GM, Price DL, Borchelt DR, Markowska AL. Normal cognitive behavior in two distinct congenic lines of transgenic mice hyperexpressing mutant APP SWE. Neurobiol Dis. 2003 Apr;12(3):194-211. PubMed.
No Available Further Reading