Mutations: APP KM670/671NL (Swedish)
Modification: APP: Transgenic
Disease Relevance: Alzheimer's Disease
Strain Name: C3B6-Tg(APP695)3Dbo/Mmjax
Genetic Background: C3H/HeJ x C57BL/6J; backcrossed to C57BL/6J
Availability: The Jackson Lab; available through the JAX MMRRC: Stock# 034828; Cryopreserved
These transgenic mice express a chimeric mouse/human APP carrying the Swedish mutation under the control of the mouse prion protein promoter. This line, C3-3, was generated in parallel with line E1-2 which also expresses APP carrying the Swedish mutation. Mice that are hemizygous for the transgene are viable and fertile and express mutant human APP at levels about 3x higher than endogenous mouse APP. They develop elevated Aβ levels with age and develop amyloid deposits in brain tissue by 18-20 months of age, but do not develop impairment in working or reference memory (Savonenko et al., 2003).
This model was previously available through The Jackson Lab as Stock# 003375.
Transgene is a chimeric mouse/human APP (isoform 695) with a "humanized" Aβ domain and the Swedish mutation under the control of the mouse prion protein promoter.
Research Models Citations
- Savonenko AV, Xu GM, Price DL, Borchelt DR, Markowska AL. Normal cognitive behavior in two distinct congenic lines of transgenic mice hyperexpressing mutant APP SWE. Neurobiol Dis. 2003 Apr;12(3):194-211. PubMed.