Research Models

APPSwe

Synonyms: APPSw, hAPPSwe (line 71) , hAPPSwe (line 72), huAPPSw

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Species: Mouse
Genes: APP
Mutations: APP KM670/671NL (Swedish)
Modification: APP: Transgenic
Disease Relevance: Alzheimer's Disease
Strain Name: B6.D2-Tg(Thy1-APPSwe)71Blt; B6.D2-Tg(Thy1-APPSwe)72Blt
Genetic Background: C57BL/6, DBA/2, crossed to C57BL/6
Availability: Available through Laurence Ozmen.

Neuropathology

Amyloid plaques by 17-18 months in the neocortex and hippocampus with detection of five to ten-fold more Aβ40 than Aβ42. Plaque burden significantly lower than in the double transgenic PS2APP. Lower levels of insoluble Aβ40 and Aβ42 than the PS2APP mouse at 16-18 months (Richards et al., 2003).

Cognition/Behavior

Unknown.

Modification Details

Transgene with human APP (isoform 751) with the Swedish mutation driven by the Thy1.2 promoter.

Note

This line of mutant APP mice was used to generate a double transgenic animal, PS2APP, by breeding to PS2(N141I) mice (Richards et al., 2003). The construct used to generate these mice was also co-injected with the construct expressing PSEN2(N141I) into C57Bl/6 zygotes to generate another double transgenic line, 152H, which is also known as PS2APP (Ozmen et al., 2009).

Availability

Contact Laurence Ozmen.

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References

Research Models Citations

  1. PS2APP (PS2(N141I) x APPswe)
  2. PS2(N141I)
  3. PS2APP

Paper Citations

  1. . PS2APP transgenic mice, coexpressing hPS2mut and hAPPswe, show age-related cognitive deficits associated with discrete brain amyloid deposition and inflammation. J Neurosci. 2003 Oct 1;23(26):8989-9003. PubMed.
  2. . Expression of transgenic APP mRNA is the key determinant for beta-amyloid deposition in PS2APP transgenic mice. Neurodegener Dis. 2009;6(1-2):29-36. PubMed.

Other Citations

  1. Laurence Ozmen

Further Reading

Papers

  1. . Generation of Abeta38 and Abeta42 is independently and differentially affected by familial Alzheimer disease-associated presenilin mutations and gamma-secretase modulation. J Biol Chem. 2008 Jan 11;283(2):677-83. PubMed.