8th International Conference on Alzheimer's Disease
and Related Disorders
Updated 17 June 2003
This conference took place in Stockholm, Sweden, on 21 -
25 July, 2002. Listen to the speakers and view their presentations
by clicking on the links below. Also read news reports related to the conference.
Kurt Jellinger: "Neuropathology of Alzheimer Disease and
Alzheimer disease (AD) morphologically shows extracellular deposition of Ab amyloid
(Ab), paired helical filaments (hyperphosphorylated tau) in neurofibrillary tangles,
neuropil threads, and dystrophic neurites. These of lesions showing a distinct sequence of spreading are associated
with loss of cortical synapses and neurons causing disruption of neuronal circuits as major correlates of dementia
and AD variants. Current diagnostic criteria are based on...Click here for more.
Philip Scheltens: "MRI in the Practical
Evaluation of Dementia: ‘Beyond Exclusion’"
This paper reviews the use of imaging techniques to aid in
the clinical diagnosis of dementia. Two approaches are distinguished.
The exclusionary approach is one in which imaging is used
to rule out diseases that would mimic or cause dementia.
Based on the literature this approach yields very little,
if any, information that was not identified clinically. The more positive approach
uses imaging as a diagnostic tool to identify changes specific
for causes of dementia. Click here for more.
Gunnar Gouras: "Subcellular Ab
Accumulation and Origin of Plaques in Alzheimer’s Disease"
We have been studying the generation and subcellular localization
of Ab neurons by biochemical
and immunocytochemical assays, and more recently have turned
to immuno-gold electron microscopy (EM) to determine the
more precise localization of Ab
peptides and amyloid precursor protein (APP) within neurons
of normal brain and to study the earliest site of Ab
accumulation and neuropathology with aging in AD mouse models
of b-amyloidosis. Click here for more.
This presentation focuses on the cell biology of the presenilins.
The role of presenilins in the cleavage of type I integral
membrane proteins, the turn over of beta-catenin and possibly
other functions in trafficking and Ca2+ signaling are discussed.
Click here for more.