Hyperinsulinemia and insulin resistance increase the
risk of Alzheimer disease as well as of vascular dementia. Numerous
studies point to a variety of possible mechanisms, including the role
of insulin signaling on amyloid-β regulation, synaptic integrity,
inflammation tau phosphorylation, brain vascular function, and energy
These findings suggest that early identification and treatment of
insulin resistance may delay or prevent Alzheimer disease and vascular
dementia. Potential interventions include physical exercise, caloric
restriction, manipulation of the diet, pharmacologic insulin
sensitization, and intranasal delivery of insulin to the brain.
In this Webinar, Suzanne Craft reviewed the evidence on the role of
insulin resistance in brain aging and dementia, and presented results
from animal and clinical studies of interventions. Joining her for a
panel discussion were Greg Cole, Suzanne de la Monte, Bill Klein, Matt
Townsend, Jose Luchsinger, and Caroline Sanz.
See Related News:
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Special Issue Explores Link Between Metabolic Disease and Dementia
Keystone: Longevity, Insulin-like Growth Factor Signaling, and Aβ Toxicity
Type 2 Diabetes and Neurodegeneration—The Plot Caramelizes
Research Brief: Diabetes—Risk Factor That Slows Cognitive Decline?
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