Posted 7 October 2002
Transgene: Human longest tau cDNA
Mutation: V337M causing frontotemporal dementia parkinsonism-17 (FTDP-17)
Promoter: PDGF-beta promoter
Mouse Strain: B6SJL
SDS-insoluble tau aggregates found in hippocampus.
Under light microscopy, neurons of irregular shape in hippocampus were immunoreactive
for paired helical filament-associated tau (as visualized by Alz-50); exhibited
Congo Red birefringence; and accumulated RNA.
Under electron microscopy, irregularly shaped neurons failed to show signs of apoptotic
cells death, instead showing signs of atrophic cell death ("dark cell degeneration:):
atrophy of both nucleus and cytoplasm with accumulations of phosphorylated tau,
increased number of ribosomes, disappearence of microtubules, and deposition of
In hippocampal slice preparation, there was attentuation of the Schaffer collateral-evoked
Tg mice showed higher overall spontaneous locomotion than non-Tg littermates throughout
testing in elevated plus maze. There were no differences in the Morris water maze.
Lab. for Alzheimer's Disease, Brain Science Institute at RIKEN
2-1 Hirosawa, Wako-Shi, Saitama 351-0198
Email: Akihiko Takashima or
Tanemura K, Murayama M, Akagi T, Hashikawa T, Tominaga T, Ichikawa M, Yamaguchi
H, Takashima A. Neurodegeneration with tau accumulation in a transgenic mouse expressing
V337M human tau. J Neurosci. 1 Jan 2002;22(1):133–141.
Tanemura K, Akagi T, Murayama M, Kikuchi N, Murayama O, Hashikawa T, Yoshiike Y,
Park JM, Matsuda K, Nakao S, Sun X, Sato S, Yamaguchi H, Takashima A. Formation
of filamentous tau aggregations in transgenic mice expressing V337M human tau. Neurobiol
Dis 2001 Dec;8(6):1036-45.Abstract.