Posted 19 December 2004
Transgene: T-N279K mice were created by microinjection of a minigene comprised of
all of the human CNS expressed exons and intronic sequences surrounding exons 2,
3 and 10. The mice express human tau protein at the same level as endogenous mouse
Promoter: Human tau
Mouse Strain: Origin: C57BL/6 x SJL hybrids
Numerous abnormal tau and phospho-tau reactive neurons and glia. The pathology resembles
that seen in patients with the N279K mutation to include tau positive tufted astrocytes.
Molecularly, tau isoforms are expressed almost exclusively with exon in the adult
mice as seen in patients with the mutation.
Mice are cognitively impaired on the radial arm water maze at 52 weeks. A percentage
of the mice develop motor deficits leading to hind limb paralysis and early demise.
Division of Neurology, Dept of Medicine
Duke University, Box 2900 DUMC,
Durham NC 27710
Phone: 919 684 5453
Fax: 919 684 6514