| Name/Symbol |
Strain Name |
Transgene/
Promoter and Regulatory Elements |
Genetic Background |
Behavioral
Phenotype |
Neurological
Characteristics |
Patents/
Availability |
Primary Citation |
| Psen2-EGFP Posted 1/23/09 |
STOCK Tg(Psen2-EGFP)244Gsat/Mmcd |
Modified BAC containing inserted EGFP upstream of targeted gene injected into pronuclei of FVB/N fertilized oocytes/ founder line DF244. |
Background: FVB/N-Swiss Webster hybrid, Generation: N1F2. |
|
|
MMRRC Cryopreserved stock# 011154-UCD. For non-profit only.
|
Gong et al., 2003 |
| NSE-hPS2(N141I) and hPS2wt |
|
pNSE-CAT promoter and hPS2(N141I) inserted in pUHD10-3/microinjected BDF1 |
Origin C57BL/6 x DBA/2, Background C57BL/6, Backcross 5 generations |
Behavior dysfunction in water maze |
Levels of hPS2, Aβ-42, caspase-3, and Cox-2 expression were modulated in tg and wt. No AD phenotype seen between mutant and wt. |
Patent filing date 11/4/02
Contact: Yong K Kim
kimyongkyu@hanmail.net
|
Hwang
et al., 2002 |
| PS2N141I Symbol: PS2 Posted 6/10/05 |
Tg.Prp-huPS2.30H |
Human FAD mutation N141I inserted into PS2 cDNA/ murine prion protein genomic fragment (pPrnpHG) promoter/microinjection into pronuclei B6D2F1 zygotes. |
Origin C57BL/6, DBA/2. Backcrossed C57BL/6 for 3N, then intercrossed F8 |
14% mortality before weaning. |
|
Contact: Laurence Ozmen
Laurence.ozmen@roche.com |
Richards
et al., 2003 |
| PS2 N141I |
|
Human PS2 cDNA with N141I/
chicken b-actin promoter |
C57BL/6
(B6)J or DBF1 females and B6N males |
N/A |
Age-dependent
increase in Aβ42, higher level of insoluble Aβ |
Unpatented
Contact Yasuo Ihara
|
Oyama
et al |
| PS2
null Updated 1/23/09 |
B6.129P-Psen2tm1Bdes/J |
Exon
5 was replaced by a hygromycin cassette under the
control of the PGK promoter |
C57B6/J
black x 129Sv |
Viable
and fertile no behavioral abnormalities. |
No
abnormal pathology, develop only mild pulmonary
fibrosis and hemorrhage with age. |
The Jackson Lab, cryopreserved, stock #005617. Use by companies or for-profit entities requires a license prior to shipping.
|
Herreman et al., 1999. |
| PS2
null |
|
Ablated PS2 gene created by the deletion of exon
5 and insertion of the neomycin resistance gene
disrupted translation of the mouse gene in ES
cells.
|
129sv/ev
x C57/blk6 |
No
behavioral abnormalities |
No
abnormal pathology |
Unpatented
|
Steiner
H et al. |
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