Updated 23 January 2009

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Name/Symbol Strain Name Transgene/ Promoter and Regulatory Elements Genetic Background Behavioral  Phenotype Neurological  Characteristics Patents/ Availability Primary Citation PS1(n-/-) conditional ko Symbol:PS1 Updated 1/23/09 B6;129P-Psen1tm1Vln/J Crossed (1) tg mice with a "floxed" PS1 gene containing 3 loxP sites and (2) mice with neuron-specific expression of Cre-recombinase / mouse thy1-gene promoter. Results in deletion of exon 7 of PS1 gene. Origin: FVB/N (Crl), Background: B6;129P (Aug-08), Generation: ?+F3 (05-Jan-09). Mice are viable and fertile with normal brain morphology. Adult mice have decreased brain Aß40 and 42 with accumulation of APP C-terminal fragments. The Jackson Lab, available, stock #007605. Use by companies or for-profit entities requires a license prior to shipping. Dewachter et al., 2002 PS1P117L (line 13) Symbol:PS1 Posted 4/1/05   Human PS1P117L (Polish) cDNA/NSE promoter/ pronuclear injection into eggs of C57Bl/6J × DBA/2J (B6D2) F1 hybrids Origin:B6D2F1, Background mixed C57Bl/6 and DBA/2J   Mice express hPS1 at 2-3X the level of the endogenous mPS1. No plaques or diffuse amyloid deposits at 2-3 months, but overproduction of the long 1-42 form of Aβ. Contact Gregory A. Elder Wen et al., 2002 PS1 Wt line 22 Symbol:PS1 Posted 4/1/05   Human wild-type PS1/NSE promoter Origin 6D2 F1 hybrids, Background mixed C57Bl/6 and DBA/2J.   Line 22, hPS1 proteins are 2-3 X the level of the endogenous mPS1. No neuropathological changes. Contact Gregory A. Elder Wen et al., 2002 Human PS1wtrescue Symbol:PS1 Posted 4/1/05   1.4 kb KpnI-BamHI fragment containing human wtPS1cDNA sequence with a KpnI-BglII-cleaved pHZ024 vector/Thy-1 promoter B6SJL No overt abnormalities observed. Human wtPS1 tg mice can rescue the PS1 knockout mouse from embryonic lethality. 6,452,065B2 filing date 5/14/98 issue date 9/17/02 These mice are no longer available. Qian et al., 1998 PS1A246ERescue Symbol:PS1 Posted 4/1/05   1.4 kb KpnI-BamHI fragment containing human PS1A246EcDNA sequence with a KpnI-BglII-cleaved pHZ024 vector/Thy-1 promoter B6SJL No overt abnormalities observed. Human PS1A246E tg mice can rescue the PS1 knockout mouse from embryonic lethality. 6,452,065B2 filing date 5/14/98 issue date 9/17/02 These mice are no longer available. Qian et al., 1998 CNS-restricted PS1cko Symbol:PS1 Posted 1/28/05   CNS-restricted PS1 deletion/ Nestin promoter/ fPS1/fPS1Δ;Nestin-Cre x fPS1/+ = +/fPS1Δ;Nestin-Cre x fPS1/fPS1 = fPS1/fPS1Δ;Nestin-Cre (PS1 cKO) and fPS1/+ (control). Origin B6/129, fPS1 backcross 12 generations, Nestin-Cre backcross 12 generations Small mice with many gross behavior deficits. Survive up to 3-4 months of age. Premature differentiation of neural progenitor cells reduces cells and neuronal populations. 45% of late-born neurons fail to migrate to their appropriate positions in the superficial cortical layer. Contact J. Shen Wines-Samuelson et al., 2005 PS1 conditional Ko (cKo) Symbol:PS1 Updated 1/28/05   Developed a floxed PS1 mouse (PS1 exons 2 and 3 are flanked by two loxP sites)/129/Sv ES cells. Developed a Cre tg mouse / aCaMKII promoter/injected into C57BL/6J xCBA embryos. Crossed fPS1 to CaM-Cre tg mice. CaM-Cre Origin: C57BL/6J x CBA hybrid, backcrossed several generations to C57BL/6J. fPS1 origin C57BL/6J x 129/Sv hybrid. Viable, no obvious phenotypic or gross abnormalities PS1 expression eliminated in neurons of cerebral cortex starting day 18. Reduction Aβ40 and Aβ42 in the adult cortex, while CTFs of APP accumulate. Mice exhibit deficits in long-term spatial memory. Contact J. Shen Yu et al., 2001. B6-G9 Symbol:PSEN-1 Updated 1/23/09 B6.129S4-Tg(PSEN1H163R)G9Btla/J 1,000 kb YAC transgene with hu PS-1 gene/H163R mutation/J1 ES cells/line G9. Origin: 129S4/SvJae; Background C57BL/6J, Generation: ?+N34+F2 (08-Jan-09). Hemizygous mutants are viable and fertile, while homozygous are non-viable. Elevated levels of Aβ peptides and earlier Aβ deposits detected when crossed to APP YAC line R.140 such as #005300 The Jackson Lab, available, Stock #006469. For research and non-profit use only. Lamb et al., 1999 PS1 M146L Updated 1/28/05   Human PS1 cDNA (VRSQ-) with M146L/ Rat PDGF b-chain (1.4 kb Xba fragment) Swiss Webster (Taconic) x B6D2F1 (taconic) No behavioral abnormalities No abnormal pathology up to 2.5 yrs of age 5,898,094 Contact Valerie McDevitt at (813) 974-2466 Duff K et al PS1 M146V Updated 7/6/04   Human PS1 cDNA (VRSQ-) with M146V/ Rat PDGF b-chain (1.4 kb Xba fragment) Swiss Webster (Taconic) x B6D2F1 (taconic) No behavior abnormalities Elevated Aβ42, altered mitocondrail activity, disregulation of calcium homoeostasis. 5,898,094 Contact Valerie McDevitt at (813) 974-2466 Duff K et al., 1996 PS1 Δexon9   Deletion of Δexon 9 of Human PS1 cDNA (VRSQ-)/ Rat PDGF b-chain (1.4 kb Xba fragment) Swiss Webster (Taconic) x B6D2F1 (taconic) No behavioral abnormalities No abnormal pathology up to 2.5 yrs of age 5,898,094 Contact Valerie McDevitt at (813) 974-2466 Duff et al., 1996 PS1 A246E   Human PS1 cDNA with A246E/ mouse thy-1 gene. The thymus specific regulatory elements in intron 3 are thereby deleted, making the resulting promoter "neuron-specific" FVB/N No behavioral abnormalities Normal up to 2 years of age, more seizures and neuronal apoptosis Unpatented Contact Paul Vandun Schneider I et al PS1 P264L    Gene targeting with the Cre-lox system, introducing P264L into the endogenous mouse PS-1 gene. CD-1 outbred background N/A Exhibit basal neurodegeneration similar to PS1 wild-type counterparts. Unpatented Contact Dorothy Flood or Steve Trusko Siman R. et al. PS1   mutated human presenilin 1 gene (M146L; hps1*) on lesion-induced sprouting C57BL/6 C57/CBA     Kadish PSI Null or C57BL/6-Psen1tm1Shn (See JAX datasheet) Symbol: Psen1 Updated 1/23/09 B6.129-Psen1tm1Shn/J A targeting construct designed to disrupt exons 2 and 3 containing a neomycin cassette was electroporated into J1 and D3 ES cells Origin: 129S7/SvEvBrd-Hprt1, Backcross: C57BL/6J, Generation: N6+4pN1, Congenic. Homozygous mutants die shortly after natural birth. Heterozygous mutants are viable and fertile. Gross skeletal malformation, impairment in neurogenesis, massive neuronal loss, hemorrhages in the CNS. Cryopreserved The Jackson Lab Stock#: 003615. Use by companies or for-profit entities requires a license prior to shipping. Shen et al. PS1 Null or Presenilin 1 (See JAX datasheet) Symbol: Psen1 Updated 1/23/09 B6;129S-Psen1tm1Shn/J A targeting construct designed to disrupt exons 2 and 3 containing a neomycin cassette was electroporated into J1 and D3 ES cells. Origin: 129S7/SvEvBrd-Hprt1, Backcross: C57BL/6J, Generation: N2. Homozygous mutants die shortly after natural birth. Heterozygous mutants are viable and fertile. Gross skeletal malformation, impairment in neurogenesis, massive neuronal loss, hemorrhages in the CNS. Cryopreserved The Jackson Lab: Stock 003822. Use of mice by companies or for-profit entities requires a license prior to shipping. Shen et al. PS1M146VKI; The Miles Miller Mouse (See JAX datasheet) Symbol: Psen1 Updated 1/23/09 B6.129-Psen1tm1Mpm/J Knock-in M146V mutation /R1 ES cells Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl<+>, Backcross: C57BL/6, Generation: N7+3F3p+N1 (28-Nov-04) Mice are viable, fertile, and normal in size. No gross physical or behavioral abnormalities. On PS1 null background mutation results in impaired associative contextual fear conditioning (Wang, 2004). Homozygous mice produce only the mutant gene product. Neurodegeneration by excitotoxin kainate treatment is increased and accelerated. On PS1 null background mutation results in reduced adult neurogenesis in the dentate gyrus (Wang, 2004). Cryopreserved The Jackson Lab: Stock 004193 Guo et al., 1999; Wang, 2004