Posted 1 April 2005
Transgene: Tg RAGE mice (see Yan) were crossed with animals expressing a mutant
form of hAPP (Tg mAPP, (see TJL #004661) driven by PDGFβ-chain promoter, and
in the C57BL/6 background.
Promoter: PDGF-β promoter for both RAGE and APP
Mouse strain: C57BL/6
TBigenic tg APP/RAGE mice displayed early abnormalities in spatial learning/memory,
accompanied by altered activation of markers of synaptic plasticity and exaggerated
neuropathologic findings, before such changes were found in single mAPP mice.
Shi Du Yan
Departments of Pathology and Surgery, Departments of Pathology and Surgery
Taub Institute for Alzheimer's Disease and the Aging Brain
College of Physicians & Surgeons of Columbia University
630 West 168th Street
New York, NY 10032, USA.
Phone: (212) 305 3958
Fax: (212) 305 5337
Arancio O, Zhang HP, Chen X, Lin C, Trinchese F, Puzzo D, Liu S, Hegde A, Yan SF,
Stern A, Luddy JS, Lue L-F, Walker DG, Roher A, Buttini M, Mucke L, Li W, Schmidt
AM, Kindy M, Hyslop PA, Stern DM, Yan SSD. RAGE potentiates Aβ-induced perturbation
of neuronal function in transgenic mice. The EMBO J. 23 (20): 4096-4105, 2004. Abstract