Posted 8 June 2010
Transgene: Human APP695 cDNA with the Arctic mutation (E693G).
Promoter: Mouse Thy1.2
Mouse Strain: C57BL/6-CBA. Backcrossed to C57BL/6 for two generations to establish
heterozygous offspring B6CBA-Tg(Thy1.2-hAPParc). Backcrossed to C57BL/6 for five
generations. Heterozygous mice are viable and fertile.
Express APParc at levels ~threefold higher than endogenous APP. Age-dependent progression
of amyloid deposition, starting in the subiculum at 7 months and spreading to the
thalamus at 18 months. Neuropathology is more severe in female mice.
Spatial learning and memory deficit in the Barnes maze test in female mice at 15
Karolinska Institutet, Dept. Neurobiology, Care Sciences and Society Karolinska
Institutet Dainippon Sumitomo Pharma Alzheimer Ctr. (KASPAC)
Novum level 5, Huddinge SE-141 57, Sweden
Phone: +46 8 585 836 19
Fax: +46 8 585 836 10
Rönnbäck A, Zhu S, Dillner K, Aoki M, Lilius L, Näslund J, Winblad B, Graff C. Progressive
neuropathology and cognitive decline in a single Arctic APP transgenic mouse model.
Neurobiol Aging. 2009 Mar 27.