Mice expressing pathogenic mutations of human genes have become a
critical tool for biomedical research and drug discovery, and nowhere
more so than in the Alzheimer field. The generation of research models
that develop some of the pathologic hallmarks of Alzheimer's has given a
sizable boost to drug discovery efforts, and has also raised many
intriguing questions about the underlying disease process. Identical
mutations result in surprisingly divergent phenotypes in different mouse
strains. Why? No model perfectly mimics the human disease. Why?
To support investigators' efforts, we are compiling this list of
research models that are relevant to understanding Alzheimer disease.
Our goal is to provide a central publication forum for quickly reporting
and updating data on all published models. We have designed tables to
facilitate comparisons of different models and to provide information on
the availability of each model.
We strive to keep these lists up to date and to improve our format and
editorial annotation. In addition to screening the published literature,
we depend on investigators to notify us of updates, corrections and to
tell us what we can do to support their work. These compendia are
collaborative endeavors involving many scientists, all of whom will be
publicly credited for their contributions.
If you would like to be involved, please contact us.
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