Mice expressing pathogenic mutations of human genes have become a
critical tool for biomedical research and drug discovery, and nowhere more so than
in the Alzheimer field. The generation of research models that develop some of the
pathologic hallmarks of Alzheimer's has given a sizable boost to drug discovery
efforts, and has also raised many intriguing questions about the underlying disease
process. Identical mutations result in surprisingly divergent phenotypes in different
mouse strains. Why? No model perfectly mimics the human disease. Why?
To support investigators' efforts, we are compiling this list of research models
that are relevant to understanding Alzheimer disease. Our goal is to provide a central
publication forum for quickly reporting and updating data on all published models.
We have designed tables to facilitate comparisons of different models and to provide
information on the availability of each model.
We strive to keep these lists up to date and to improve our format and editorial
annotation. In addition to screening the published literature, we depend on investigators
to notify us of updates, corrections and to tell us what we can do to support their
work. These compendia are collaborative endeavors involving many scientists, all
of whom will be publicly credited for their contributions.
If you would like to be involved, please