Craig-Schapiro R, Perrin RJ, Roe CM, Xiong C, Carter D, Cairns NJ, Mintun MA, Peskind ER, Li G, Galasko DR, Clark CM, Quinn JF, D'Angelo G, Malone JP, Townsend RR, Morris JC, Fagan AM, Holtzman DM. YKL-40: a novel prognostic fluid biomarker for preclinical Alzheimer's disease. Biol Psychiatry. 2010 Nov 15;68(10):903-12. PubMed.

AlzBiomarker Database

Meta-Analysis

Curated Study Data

Biomarker
(Source)		 Cohort
(N)		 Measurement
Mean ± SD		 Method;
Assay Name;
Manufacturer		 Diagnostic
Criteria
Aβ42
(CSF)		 AD-
Mild AD
(29)		 351 ± 118
pg/mL		 ELISA;
Innotest;
Innogenetics		 McKhann et al., 1984
Aβ42
(CSF)		 AD-
Very Mild AD
(65)		 446 ± 230
pg/mL		 ELISA;
Innotest;
Innogenetics		 McKhann et al., 1984
Aβ42
(CSF)		 CTRL-
CNC
(198)		 605 ± 240
pg/mL		 ELISA;
Innotest;
Innogenetics
YKL-40
(CSF)		 AD-
Mild AD
(24)		 422.2 ± 30†
ng/mL		 ELISA;
Other/Not Specified;
Quidel Corporation		 McKhann et al., 1984
YKL-40
(CSF)		 AD-
Mild AD
(29)		 351.7 ± 22.6†
pg/mL		 ELISA;
Other/Not Specified;
Quidel Corporation		 McKhann et al., 1984
YKL-40
(CSF)		 AD-
Very Mild AD
(65)		 358.9 ± 16.9†
pg/mL		 ELISA;
Other/Not Specified;
Quidel Corporation		 McKhann et al., 1984
YKL-40
(CSF)		 CTRL-
CNC
(198)		 282.1 ± 6.7†
pg/mL		 ELISA;
Other/Not Specified;
Quidel Corporation
YKL-40
(CSF)		 CTRL-
CNC
(24)		 293.6 ± 23.9†
ng/mL		 ELISA;
Other/Not Specified;
Quidel Corporation
YKL-40
(Plasma)		 AD-
Mild AD
(29)		 91.9 ± 15†
pg/mL		 ELISA;
Other/Not Specified;
Quidel Corporation		 McKhann et al., 1984
YKL-40
(Plasma)		 AD-
Very Mild AD
(65)		 81.1 ± 8†
pg/mL		 ELISA;
Other/Not Specified;
Quidel Corporation		 McKhann et al., 1984
YKL-40
(Plasma)		 CTRL-
CNC
(198)		 62.5 ± 3.4†
pg/mL		 ELISA;
Other/Not Specified;
Quidel Corporation
tau-p181
(CSF)		 AD-
Mild AD
(29)		 77 ± 38
pg/mL		 ELISA;
Innotest;
Innogenetics		 McKhann et al., 1984
tau-p181
(CSF)		 AD-
Very Mild AD
(65)		 85 ± 44
pg/mL		 ELISA;
Innotest;
Innogenetics		 McKhann et al., 1984
tau-p181
(CSF)		 CTRL-
CNC
(198)		 55 ± 25
pg/mL		 ELISA;
Innotest;
Innogenetics
tau-total
(CSF)		 AD-
Mild AD
(29)		 552 ± 263
pg/mL		 ELISA;
Innotest;
Innogenetics		 McKhann et al., 1984
tau-total
(CSF)		 AD-
Very Mild AD
(65)		 539 ± 276
pg/mL		 ELISA;
Innotest;
Innogenetics		 McKhann et al., 1984
tau-total
(CSF)		 CTRL-
CNC
(198)		 304 ± 161
pg/mL		 ELISA;
Innotest;
Innogenetics

† Mean ± SEM

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AlzBiomarker

  1. AD vs CTRL : Aβ42 (CSF)
  2. CTRL vs AD : Aβ42 (CSF)
  3. AD vs CTRL : YKL-40 (CSF)
  4. AD vs CTRL : YKL-40 (Plasma and Serum)
  5. CTRL vs AD : YKL-40 (CSF)
  6. CTRL vs AD : YKL-40 (Plasma and Serum)
  7. AD vs CTRL : tau-p181 (CSF)
  8. CTRL vs AD : tau-p181 (CSF)
  9. AD vs CTRL : tau-total (CSF)
  10. CTRL vs AD : tau-total (CSF)

Mutations