Adlard PA, Perreau VM, Pop V, Cotman CW.
Voluntary exercise decreases amyloid load in a transgenic model of Alzheimer's disease.
J Neurosci. 2005 Apr 27;25(17):4217-21.
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This is a very exciting study. It should be discussed together with the recent paper from the Sisodia group (Lazarov et al., 2005). Is the effect seen in the Lazarov et al. study due to exercise alone? Alternatively, do exercise and environment enrichment enhance learning and reduce Aβ via an overlapping mechanism?
Lazarov O, Robinson J, Tang YP, Hairston IS, Korade-Mirnics Z, Lee VM, Hersh LB, Sapolsky RM, Mirnics K, Sisodia SS.
Environmental enrichment reduces Abeta levels and amyloid deposition in transgenic mice.
Cell. 2005 Mar 11;120(5):701-13.