Raices M, Maruyama H, Dillin A, Karlseder J.
Uncoupling of longevity and telomere length in C. elegans.
PLoS Genet. 2005 Sep;1(3):e30.
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This paper raises several provocative issues. It also lends further support to those who believe that the secondary function of telomeres is to serve as a checkpoint for uncontrolled cellular proliferation. This makes sense in tissues that continue to undergo mitosis. But it raises the question, "What is the function of telomeres in non-replicative cells?" They must have some function; what is their function and why are they there? I have an idea but would like to hear from others first.