. A synthetic peptide blocking the apolipoprotein E/beta-amyloid binding mitigates beta-amyloid toxicity and fibril formation in vitro and reduces beta-amyloid plaques in transgenic mice. Am J Pathol. 2004 Sep;165(3):937-48. PubMed.

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  1. This work points to the possible central role of the ApoE-Abeta interaction in Abeta amyloidosis. Whether Abeta plaques, ApoE-Abeta complexes, or some other forms of Abeta oligomer is primarily neurotoxic remains an open question.

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