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Survival of cultured neurons from amyloid precursor protein knock-out mice against Alzheimer's amyloid-beta toxicity and oxidative stress.
J Neurosci. 1998 Aug 15;18(16):6207-17.
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This paper is essentially a negative result but is undoubtedly important. Their data clearly indicate that amyloid-burden in AD cannot be explained by the simple analogy of prion disease. Very nice.