. Surface plasmon resonance and nuclear magnetic resonance studies of ABAD-Abeta interaction. Biochemistry. 2007 Feb 20;46(7):1724-31. PubMed.

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  1. My collaborators, Dr. Wang's group, extended our initial studies and
    just published NMR results on Aβ-ABAD binding, which forms a direct
    link between Aβ and mitochondrial toxicity. This paper examined the
    thermodynamics as well as conformational and functional consequences
    of the Aβ-ABAD interaction. Surface plasma resonance showed that
    the binding between Aβ and ABAD is mainly driven by hydrophobic
    interactions. NMR clearly demonstrated that Aβ binding results in
    the loss of the essential cofactor NAD from the ABAD enzyme. These new
    data are important for understanding the mechanism of Aβ toxicity
    and for the search for drugs that disrupt the Aβ-ABAD interaction
    in Alzheimer disease.