. Simvastatin strongly reduces levels of Alzheimer's disease beta -amyloid peptides Abeta 42 and Abeta 40 in vitro and in vivo. Proc Natl Acad Sci U S A. 2001 May 8;98(10):5856-61. PubMed.

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  1. Exciting data, which with animal data of Sparks and Refolo and colleagues, and clinical data from Wolozin and Jick and colleagues really puts cholesterol center stage in terms of APP metabolism. Is this the connection between ApoE and amyloid?

  2. This is certainly interesting for the possible clinical treatment as well as to see a mechanism to produce Abeta in relation of cholesterol and apo E function.

  3. Please do not miss the following letters to complete the above comment by Dr.Hardy:

    Alzheimer’s anti-amyloid vaccination and statins: two approaches, one dogma. The time for change.
    Koudinov and Koudinova
    BMJ 20 March 2002 [ Full Text ] ;

    Alzheimer's disease and amyloid beta protein
    Koudinov AR et al
    Science online, Published 25 June 2002
    [ Full Text ]