Witty CF, Gardella LP, Perez MC, Daniel JM. Short-term estradiol administration in aging ovariectomized rats provides lasting benefits for memory and the hippocampus: a role for insulin-like growth factor-I. Endocrinology. 2013 Feb;154(2):842-52. PubMed.
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College of Medicine, University of Arizona
Earlier research by Garcia-Segura and colleagues demonstrated a synergistic interaction between estrogen and IGF-1 signaling. These findings by Witty et al. provide an important new development in our understanding of the functional implications of the interaction between these pathways.
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