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Wu CC, Chawla F, Games D, Rydel RE, Freedman S, Schenk D, Young WG, Morrison JH, Bloom FE. Selective vulnerability of dentate granule cells prior to amyloid deposition in PDAPP mice: digital morphometric analyses. Proc Natl Acad Sci U S A. 2004 May 4;101(18):7141-6. PubMed.
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Is Cdc42 expressed in these cell types displaying dendritic reductions in the PDAPP mice? Scott et al. (1) find that Cdc42 mutant VS neurons display increased dendritic length. Zhu et al. (2) find that Cdc42 is upregulated in select neuronal populations in AD. Might it suggest that this upregulation may explain reduced dendritic length in AD?
References:
Scott EK, Reuter JE, Luo L. Small GTPase Cdc42 is required for multiple aspects of dendritic morphogenesis. J Neurosci. 2003 Apr 15;23(8):3118-23. PubMed.
Zhu X, Raina AK, Boux H, Simmons ZL, Takeda A, Smith MA. Activation of oncogenic pathways in degenerating neurons in Alzheimer disease. Int J Dev Neurosci. 2000 Jul-Aug;18(4-5):433-7. PubMed.
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