. S-adenosylmethionine is decreased in the cerebrospinal fluid of patients with Alzheimer's disease. Neurodegener Dis. 2010;7(6):373-8. PubMed.

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  1. These CSF data indicating reduced methylation capacity in Alzheimer disease are consistent with our finding of reduced expression of epigenetic marks in AD brain (Mastroeni et al., 2009; Mastroeni et al., in press). It seems noteworthy that the epigenetic reductions we have found in brain are reflected in CSF.

    References:

    . Epigenetic differences in cortical neurons from a pair of monozygotic twins discordant for Alzheimer's disease. PLoS One. 2009;4(8):e6617. PubMed.