. Reversal of Alzheimer's-like pathology and behavior in human APP transgenic mice by mutation of Asp664. Proc Natl Acad Sci U S A. 2006 May 2;103(18):7130-5. PubMed.


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  1. It is becoming increasingly evident that different flavors of APP/Aβ may modulate different functions. This paper contributes additional information to this topic.

  2. This paper, again, indicates that Abeta is not the sole factor for AD development. It will be very exciting to see how all the contributing factors (e.g oxidative stress, protein synthesis/degradation, calcium etc) interact in the development of AD.