This is a nice review of the state of the art in applying viral vectors to treat Parkinson disease. Kirik and Bjorklund also have been involved in interesting work on modeling PD via focal expression of α-synuclein using viral vectors (e.g., Eslamboli et al., 2007).
References:
Eslamboli A, Romero-Ramos M, Burger C, Bjorklund T, Muzyczka N, Mandel RJ, Baker H, Ridley RM, Kirik D.
Long-term consequences of human alpha-synuclein overexpression in the primate ventral midbrain.
Brain. 2007 Mar;130(Pt 3):799-815.
PubMed.
Comments
Emory University
This is a nice review of the state of the art in applying viral vectors to treat Parkinson disease. Kirik and Bjorklund also have been involved in interesting work on modeling PD via focal expression of α-synuclein using viral vectors (e.g., Eslamboli et al., 2007).
References:
Eslamboli A, Romero-Ramos M, Burger C, Bjorklund T, Muzyczka N, Mandel RJ, Baker H, Ridley RM, Kirik D. Long-term consequences of human alpha-synuclein overexpression in the primate ventral midbrain. Brain. 2007 Mar;130(Pt 3):799-815. PubMed.
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