. Rescue of aging-associated decline in Dnmt3a2 expression restores cognitive abilities. Nat Neurosci. 2012 Jul 1; PubMed.

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  1. This is a fascinating study at several different levels, and a very
    important contribution to our understanding of aging-related memory
     loss.

    It builds significantly on a recent series of studies investigating both
    DNA methylation and histone acetylation in aging-related cognitive
     decline.

    It also is an important contribution in the general area of
    understanding the role of neuro-epigenetic mechanisms in memory
     formation.

    There are several key findings in the paper. First, the identification
    of Dnmt3a2 as an activity-regulated immediate early gene in the CNS.
    Second, identifying the critical role of Dnmt3a2 in memory in both young
    animals and in aging-related cognitive decline. Finally, this is a big
    step forward in beginning to understand the quite mysterious mechanisms
    that are involved in memory-associated DNA methylation.

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