Kanne SM, Balota DA, Storandt M, McKeel DW, Morris JC.
Relating anatomy to function in Alzheimer's disease: neuropsychological profiles predict regional neuropathology 5 years later.
Neurology. 1998 Apr;50(4):979-85.
PubMed.
This represents a tremendous amount of careful work. The neuropathological data obtained when the patients died 5 years after testing showed that cored senile plaques were 'systematically related' to psychometric factors. This represents on of the more recent papers showing a relationship of plaques or plaque burden to cognitive function. There are also conflicting papers that emphasizes NFT in cognitive decline in AD. These conflicting data remain to be conclusively resolved.
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Banner Research Institute
This represents a tremendous amount of careful work. The neuropathological data obtained when the patients died 5 years after testing showed that cored senile plaques were 'systematically related' to psychometric factors. This represents on of the more recent papers showing a relationship of plaques or plaque burden to cognitive function. There are also conflicting papers that emphasizes NFT in cognitive decline in AD. These conflicting data remain to be conclusively resolved.
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