. A recessive mutation in the APP gene with dominant-negative effect on amyloidogenesis. Science. 2009 Mar 13;323(5920):1473-7. PubMed.

Recommends

Please login to recommend the paper.

Comments

Make a Comment

To make a comment you must login or register.

Comments on Primary Papers and News

  1. There may be a reversible formation of dimers in the APP molecule, before being cleaved by γ-secretase and the subsequent formation of Aβ dimers, thus preserving the molecule for cleavage by α-secretase.

    Data provided by this extraordinary article based on a mutation of the amino-terminal region of Aβ in its precursor molecule APP (changes in its primary sequence trigger peptide assembly and fibril formation) point to this possibility, since the relationship between the carboxy-terminal fragments generated by β- and α-secretase (1.9 ± 0.2 increase in C99: C83 ratio in patient's fibroblasts) implies double the rate of β product versus α in the mutant APP.

  2. The identification of two families with homozygous APP variants (Tomiyama et al., 2008 and now Di Fede et al., 2009) is interesting, but the linkage analysis in neither pedigree is sufficient for us to be sure that the mutations are pathogenic, let alone sufficient for us to tell whether they act in a co-dominant or recessive fashion. The homozygosity in both families is almost certainly caused by unrecognized consanguinity and this is common even in ostensibly outbred populations (Nalls et al., 2009). Thus, in both cases it is still possible that the variants are simply harmless polymorphisms or that they additively increase risk of disease. In both families, it might be informative to carry out whole genome genotyping to see which other loci are homozygous. Interpretation of these variants as recessive is premature.

    References:

    . A new amyloid beta variant favoring oligomerization in Alzheimer's-type dementia. Ann Neurol. 2008 Mar;63(3):377-87. PubMed.

    . A recessive mutation in the APP gene with dominant-negative effect on amyloidogenesis. Science. 2009 Mar 13;323(5920):1473-7. PubMed.

    . Measures of autozygosity in decline: globalization, urbanization, and its implications for medical genetics. PLoS Genet. 2009 Mar;5(3):e1000415. PubMed.

    View all comments by John Hardy
  3. I recommend the primary paper.

    View all comments by J. Lucy Boyd

This paper appears in the following:

News

  1. Good Gene, Bad Gene?—New APP Variant May Be Both