Blom ES, Giedraitis V, Zetterberg H, Fukumoto H, Blennow K, Hyman BT, Irizarry MC, Wahlund LO, Lannfelt L, Ingelsson M. Rapid progression from mild cognitive impairment to Alzheimer's disease in subjects with elevated levels of tau in cerebrospinal fluid and the APOE epsilon4/epsilon4 genotype. Dement Geriatr Cogn Disord. 2009;27(5):458-64. Epub 2009 May 7 PubMed.

AlzBiomarker Database

Meta-Analysis

Curated Study Data

Biomarker
(Source)		 Cohort
(N)		 Measurement
Mean ± SD		 Method;
Assay Name;
Manufacturer		 Diagnostic
Criteria
Aβ42
(CSF)		 AD
(47)		 66 ± 34
pM		 ELISA;
Other/Not Specified;
In-house		 McKhann et al., 1984
Aβ42
(CSF)		 CTRL-
CNC
(35)		 98 ± 47
pM		 ELISA;
Other/Not Specified;
In-house
Aβ42
(CSF)		 MCI-AD
(14)		 91 ± 71
pM		 ELISA;
Other/Not Specified;
In-house		 Petersen et al., 1999; McKhann et al., 1984
Aβ42
(CSF)		 MCI-Stable
(14)		 88 ± 48
pM		 ELISA;
Other/Not Specified;
In-house		 Petersen et al., 1999
tau-p181
(CSF)		 AD
(47)		 63 ± 25
ng/L		 ELISA;
Innotest;
Innogenetics		 McKhann et al., 1984
tau-p181
(CSF)		 CTRL-
CNC
(35)		 41 ± 14
ng/L		 ELISA;
Innotest;
Innogenetics
tau-p181
(CSF)		 MCI-AD
(14)		 74 ± 45
ng/L		 ELISA;
Innotest;
Innogenetics		 Petersen et al., 1999; McKhann et al., 1984
tau-p181
(CSF)		 MCI-Stable
(14)		 38 ± 16
ng/L		 ELISA;
Innotest;
Innogenetics		 Petersen et al., 1999
tau-total
(CSF)		 AD
(47)		 619 ± 291
ng/L		 ELISA;
Innotest;
Innogenetics		 McKhann et al., 1984
tau-total
(CSF)		 CTRL-
CNC
(35)		 248 ± 166
ng/L		 ELISA;
Innotest;
Innogenetics
tau-total
(CSF)		 MCI-AD
(14)		 621 ± 418
ng/L		 ELISA;
Innotest;
Innogenetics		 Petersen et al., 1999; McKhann et al., 1984
tau-total
(CSF)		 MCI-Stable
(14)		 252 ± 216
ng/L		 ELISA;
Innotest;
Innogenetics		 Petersen et al., 1999

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AlzBiomarker

  1. AD vs CTRL : Aβ42 (CSF)
  2. CTRL vs AD : Aβ42 (CSF)
  3. MCI-AD vs MCI-Stable : Aβ42 (CSF)
  4. AD vs CTRL : tau-p181 (CSF)
  5. CTRL vs AD : tau-p181 (CSF)
  6. MCI-AD vs MCI-Stable : tau-p181 (CSF)
  7. AD vs CTRL : tau-total (CSF)
  8. CTRL vs AD : tau-total (CSF)
  9. MCI-AD vs MCI-Stable : tau-total (CSF)