. Protofibrillar intermediates of amyloid beta-protein induce acute electrophysiological changes and progressive neurotoxicity in cortical neurons. J Neurosci. 1999 Oct 15;19(20):8876-84. PubMed.

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  1. In the news article cited above, two important facts need clarification. First, protofibrils are fibrillar. Second, the first demonstration that protofibrils were neurotoxic was published by my group, in collaboration with Drs. Hartley, Selkoe, and others, in Walsh et al. J Biol Chem on Sept 3.

    References:

    . Amyloid beta-protein fibrillogenesis. Structure and biological activity of protofibrillar intermediates. J Biol Chem. 1999 Sep 3;274(36):25945-52. PubMed.

    View all comments by David Teplow
  2. Please see the following letters in Science and BMJ related to this article: Alzheimer's disease and amyloid beta protein Koudinov AR et al Science online,> Published 25 June 2002 [ Full Text ] Amyloid hypothesis, synaptic function, and Alzheimer’s disease, or: Beware: the dogma is revitalized. Koudinov and Koudinova BMJ 15 May 2002 [ Full Text ]

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