Sudoh S, Kawamura Y, Sato S, Wang R, Saido TC, Oyama F, Sakaki Y, Komano H, Yanagisawa K. Presenilin 1 mutations linked to familial Alzheimer's disease increase the intracellular levels of amyloid beta-protein 1-42 and its N-terminally truncated variant(s) which are generated at distinct sites. J Neurochem. 1998 Oct;71(4):1535-43. PubMed.

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    • User Profile Image Hiroshi Mori
      Osaka City University Medical School
    • Posted:

    The effect of PS1 mutation on amyloid is significant. Little concern was paid to amyloid speceis in the insoluble fraction including intracellular beside the soluble fraction. This paper gives us further knowledge to understand the PS1 function in cells.

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