. PINK1/Parkin-mediated mitophagy is dependent on VDAC1 and p62/SQSTM1. Nat Cell Biol. 2010 Feb;12(2):119-31. PubMed.

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  1. The authors did a marvelous job in providing biochemical and cell biological evidence linking the Pink1/parkin pathway to mitochondrial autophagy. This adds significant new insights into the mechanisms by which the Pink1/parkin pathway regulates mitochondrial morphology and function. What remains to be determined, though, is the in vivo relevance of the findings to dopaminergic neuron maintenance and survival. This is particularly important given recent studies in Drosophila that argue against a role of autophagy in Pink1/parkin pathogenesis (Tain et al., 2009).