. PEP-19 immunohistochemistry defines the basal ganglia and associated structures in the adult human brain, and is dramatically reduced in Huntington's disease. Neuroscience. 1998 Oct;86(4):1055-63. PubMed.

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  1. We believe that the dramatic reduction of the calmodulin binding protein, PEP-19, in basal ganglia in Huntington's disease, but not in Parkinson's disease or Downs, may relate to the regional neuronal vulnerability of this disease as well as to a potential mechanism for this vulnerability.

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