. A patient with dementia with Lewy bodies and codon 232 mutation of PRNP. Neurology. 2002 Nov 26;59(10):1619-21. PubMed.

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  1. An interesting and provocative paper. If the M232R mutation is pathogenic, then this suggests that DLB may be a alternative expression of prion disease. It is worth noting that Ghetti has published (in abstract form only) that other prion mutations have both tangles and Lewy bodies.