Ito D, Seki M, Tsunoda Y, Uchiyama H, Suzuki N.
Nuclear transport impairment of amyotrophic lateral sclerosis-linked mutations in FUS/TLS.
Ann Neurol. 2010 Dec 8;
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A nice demonstration that the inability of regulatory proteins to enter the nucleus in a functional form causes translational dysregulation and neuronal degeneration (see also the recent ARF story on TDP-43).